1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide

  • IUPAC: 3 - ( Ethyliminomethylidenamino ) - N, N -dimethyl -propan- 1-amine
  • EDC
  • EDAC
  • EDCI
  • C8H17N3
  • C8H18N3Cl (hydrochloride)
  • C9H20N3I ( Methyliodidsalz )
  • 25952-53-8 (hydrochloride)
  • 22572-40-3 ( Methyliodidsalz )
  • 1892-57-5 (free base)
  • Pale yellow, clear liquid
  • Colorless to pale-yellow solid ( hydrochloride)
  • Liquid
  • Solid ( hydrochloride)
  • Fixed ( Methyliodidsalz )

0.88 g · cm -3

47-48 ° C ( 36 Pa) (free base)

  • Well in dichloromethane, DMF and THF
  • Soluble in water (hydrochloride)

Risk

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1-ethyl- 3-(3 -dimethylaminopropyl) carbodiimide (EDC or EDAC ) is a reactive organic compound is selected from the group of the carbodiimides, which is frequently used in synthetic chemistry. Because of the ease of handling, the hydrochloride is often used instead of the free base.

Use and characteristics

EDC is frequently used for the synthesis of carboxamides and biochemistry to chemical cross-linking (cross- linking) of proteins. In contrast to the resulting dicyclohexylcarbodiimide at carboxamide urea synthesis can be easily separated. Like most carbodiimides hydrolyzes the substance in aqueous solution; in the acidic pH range, this is done slowly.

Safety

The free base is irritating to eyes, mucous membranes and skin and acts as a contact allergen. On combustion, toxic gases such as carbon monoxide and oxides of nitrogen.

CAS registry number Dangerous Substances Directive (67/548/EEC) Base (chemistry) N,N'-Dicyclohexylcarbodiimide Hydrolysis Digital Object Identifier
9028
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