Acceptable daily intake

The Acceptable Daily Intake (ETD ) (English: Acceptable Daily Intake, ADI) means the dose of a substance such as a food additive, pesticide or a drug that is considered in life- long daily intake as medically safe. If it is unwanted impurities, this is called a tolerable daily intake ( engl. Tolerable Daily Intake, TDI )

Indicated is the ETD value in milligrams or micrograms per kilogram of body weight per day. Synergistic effects ( interaction of various food additives ) are only partially taken into account.

Setting the limits

Determines the ETD value is usually by feeding studies in rats and mice. This is the substance to be examined offered or forced fed in different high dosages. In this way, it is to find a dose at which no visible damage occurs ( No Observable ( Adverse ) Effect Level ( NOEL or NOAEL ) ). Divided by a safety factor of 100 results in the ETD value.

The safety factor is not always the same. It takes into account the portability of the experiment to other individuals of the test species (10 × ) and humans ( 10 × ). It can be raised or lowered depending on the substance. A conclusive explanation of why he needs to have the particular level, there is not. Substances that have no toxicity or other harmful effects, obtain an unlimited ETD value (ADI not limited), occasionally a preliminary ETD value will be awarded.

About the determination of ETD value decide International expert committees:

  • In Germany, the Federal Institute for Risk Assessment is concerned with the derivation of the ETD.
  • In the European Union, the European Food Safety Authority (EFSA ) in Parma is responsible for the derivation of the ETD.
  • International a panel of experts from the Food and Agriculture Organization (FAO ) and the World Health Organization ( WHO), JECFA (Joint FAO / WHO Expert Committee on Food Additives )

Derived limits

Be from the TDI values ​​taking into account other routes of exposure for individual substances that can migrate from consumer products with food contact into it, the specific migration limits ( Specific Migration Limits) calculated. These are expressed in milligrams per kilogram of food or Lebensmittelsimulant. Here, a consumption of 1 kg or 200 g in fatty foodstuffs, and a body weight of 60 kg is assumed.

No-observed-adverse-effect level Food contact materials
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