Acitretin

• IUPAC: (2E, 4E, 6E, 8E ) -9 - (4- methoxy-2 ,3,6- trimethylphenyl) -3,7- dimethylnona -2 ,4,6,8 - tetraenolsäure

• 55079-83-9
• 925701-88-8 (sodium salt)

D05BB02

Retinoids

Control of cell growth and the maturation of cells of the cornea

Fixed

228-230 ° C

4.2

0.00007 g · l-1 in water at 25 ° C

Risk

> 4000 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Acitretin is a retinoid, which is used as a drug in the treatment of psoriasis and other skin diseases.

Chemistry

Acitretin is the non-proprietary name ( INN) for (2E, 4E, 6E, 8E ) -9 - (4- methoxy-2 ,3,6- trimethylphenyl) -3,7- dimethylnona -2 ,4,6,8 - tetraenolsäure ( according to IUPAC). It is a derivative of vitamin A.

Operation

Acitretin is used in medicines for psoriasis, but is also used in keratinization disorders or other skin diseases. Acitretin acts on the growth of the cells and the maturation of cells of the cornea and controls them. In addition, acitretin affects the immune reactions that take place in the dermis. Just these two mechanisms are subject to changes in psoriasis. The active ingredient is used, when an external treatment does not abut satisfactorily.