Acriflavinium chloride
- Trypaflavine
- Neutroflavin
- Euflavin
- C13H12ClN3 and
- C14H14ClN3
- 69235-50-3
- 8063-24-9 (old, deleted CAS number hydrochloride)
R02AA13
Reddish-brown crystalline powder
Antiseptics
260 ° C ( decomposition above 130 ° C)
Good in water ( 300 g · l-1 at 20 ° C)
Risk
1048 mg · kg -1 ( LD50, rat, oral)
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Acriflaviniumchlorid is a mixture of substances, which as a drug ( antiseptic in the mouth and throat ) applies. It was patented in 1929 by the I. G. colors.
Chemically, it involves a mixture of about two-thirds of 3,6 -diamino -10 - methylacridiniumchlorid ( C14H14ClN3 ) and about one third 3.6 - Diaminoacridinhydrochlorid ( C13H12ClN3 ), of which the former is a quaternary ammonium compound. Both of these compounds are derivatives of acridine.
Effect
Acridine derivatives are active against gram-positive bacteria. Acriflaviniumchlorid intercalates into nucleic acids and thus inhibits the growth of bacteria and viruses. According to a study by the International Agency for Research on Cancer ( IARC ), it is however probable carcinogen.
Other uses
Acriflaviniumchlorid is also used for vital staining. Earlier it was 3,6 -diamino -10 - methylacridiniumchlorid under the name trypaflavine as a means against African Trypanosomiasis ( " sleeping sickness "), whose excitation is one of the trypanosomes used.