Aglepristone

11β - [p- (dimethylamino) phenyl] - 17β -hydroxy- 17α -(Z) - (1- propyenyl ) estra -4 ,9-dien -3-one

QG03XB90

Antiprogestin

Template: Infobox chemical / molecular formula search available

Aglepristone (trade name Alizin ® ad us. Vet. ) Is employed in veterinary medicine synthetic anti-hormone. Is a derivative of Mifepristons used in human medicine.

Operation

The drug is approved for dogs and cats.

Aglepristone is a so-called anti-progestin, a hormone -like steroid, which has a high binding ability ( affinity) of progesterone receptors, but not progesterone effect. Since it blocks the receptors for this hormone to the uterus (womb), it can not achieve its, the pregnancy -maintaining effect. The blood level of progesterone is not affected.

Use

Dog

Used the drug in dogs to prevent the embedding of embryos in the uterus ( Nidationsverhütung ) or to abort an unwanted pregnancy (artificial abortion). The latter is carried out safely and to the 45th day of pregnancy until the 25th day of pregnancy 100%.

In addition aglepristone can be used to initiate a birth from the 48th day of pregnancy.

Furthermore, the drug is suitable for conservative treatment of purulent uterine infection ( pyometra ). It leads to an opening of the cervix ( cervix ) and due to the increased motility of the uterus to the exclusion of the pus. After one to three weeks is carried out, a complete emptying of the uterus. For conservative treatment of pyometra repeated doses and the additional administration of broad-spectrum antibiotics are necessary. In cystic hyperplasia of the endometrium, this can be further enhanced by the drug.

Cat

In the cat aglepristone can also be used for the conservative Pyometrabehandlung. Moreover, it can be used for treatment of feline Fibroadenomatose ( hyperplasia of the mammary gland ).