Ajmalicine

  • Raubasine
  • 19α -methyl- 18 -oxa -16 ,17- didehydro - yohimbane -16 - carboxylic acid methyl ester

258 ° C

Poorly in water

Attention

Template: Infobox chemical / molecular formula search available

Ajmalicine (syn. raubasine ) is an indole alkaloid from the roots of Indian snake root ( Rauvolfia serpentina ). In Germany, the active ingredient is not commercially available.

Pharmacological properties

Ajmalicine has antihypertensive properties and is therefore medically, used as a single agent in arterial hypertension, especially in arrhythmia. The maximum single dose is 50 mg, the maximum daily dose of 400 mg. Overdoses lead to bradycardia, ataxia, and convulsions; additionally massive gastrointestinal complaints can be reported. In children, the smallest known toxic dose ( TDLo ) is 12.5 mg / kg.

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