Aminomethylbenzoic acid

4 - (aminomethyl ) benzoic acid (IUPAC)

B02AA03

Fibrinolysis

> 300 ° C

Attention

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The para- aminomethyl benzoic acid (trade name: Pamba ® ( D) Manufacturer: Nycomed) is a structurally related to the amino acid lysine substance ( analogue) and belongs to the ε -amino carboxylic acids. As a drug it is used medically to promote hemostasis.

PAMBA belongs to the group of anti-fibrinolytic agents, that is, the substance inhibits clot breakdown ( fibrinolysis ).

Effect

Para- aminomethyl benzoic acid inhibits by binding to the lysine Plasminbindungsplatz for the formation of active plasmin from plasminogen. Characterized the addition of plasmin on fibrin and fibrinogen, is suppressed, and as a result, the clot dissolution ( fibrinolysis ) is inhibited.

The mode of action is similar to that of the structurally similar ε -amino carboxylic acid tranexamic acid.

The elimination half -life in blood plasma is about one to two hours for a duration of between four and six hours. PAMBA is mostly excreted unchanged via the kidneys.

Para- aminomethyl benzoic acid is well absorbed and can be administered both parenterally as well as orally.

Application

In medicine, para- aminomethyl benzoic acid is used, inter alia, as an antidote for the treatment of hyperfibrinolysis caused by fibrinolytic agents, or in rare hereditary disorders in the production of fibrinolysis inhibitors.

Treatment with para- aminomethyl benzoic acid should be under the supervision by a physician experienced in the treatment of coagulation disorders doctor and only when other therapeutic measures are not sufficient.