Anaphase-promoting complex

The anaphase - promoting complex / cyclo some (APC / C) - the anaphase -promoting complex or cyclosome the - is an enzyme complex that occurs in the nuclei of all eukaryotes. The complex consists of a dozen subunits, several of which possess the enzyme activity of ubiquitin ligases. These subunits of the complex catalyzes the connection of one or more ubiquitin molecules to multiple regulatory proteins, which this for the enzymatic protein degradation ( proteolysis ) marks in the proteasome. Among the best known substrates of APC / C include cyclin A, cyclin B and securin, the during mitosis in a time strictly observing sequence ubiquitin is attached, which they will eventually dismantled. APC / C is thus the major molecular regulator of the timing of mitosis, or their G1 phase and chromosome segregation.

During infection with cytomegalovirus cell cycle by inactivating the APC / C is permanently disrupted.

In humans, the following proteins for APC / C include: APC1, APC2, APC3 ( CDC27 ), APC4, Apc5, APC6 ( Cdc16 ), APC7, APC8 ( CDC23 ), APC10, APC11, APC12 ( CDC26 ), APC13, APC15, APC16.

In addition to the main unit of the complex of the APC / C requires the proteins CDC20 Mad2L1 and to achieve optimal enzyme activity and substrate specificity. However, these are no longer formally to the complex