Barry Trost

Barry M. Trost ( born June 13, 1941 in Philadelphia ) is an American chemist and professor of chemistry at Stanford University.

Life and work

He studied at the University of Pennsylvania. For his doctoral thesis on the structure and reactivity of enolate anions, he moved to the Massachusetts Institute of Technology in the laboratory of Herbert O. House. He was from 1965 to 1987 professor at the University of Wisconsin and then moved to Stanford University.

The Tsuji -Trost reaction and the Trost ligand are named after him. He is one of claims to one of the 50 most cited chemists in the world.

The research focuses on the synthesis, the development of new reactions and reagents as well as the development of a network of reactions ( see also tandem reaction ) to build complex target molecules from simple molecules. For the development of new reactions, the route of the so-called chemical enzymes followed, which are non-peptidic transition-metal- based catalysts with chemo-, regio-and enantioselective properties. Target molecules are produced by, inter alia, metal catalysis, ring compounds having more than six ring members.

Awards

Barry Trost received numerous honors and awards, including the Alfred P. Sloan Foundation Fellow 1967-69; the ACS Award in Pure Chemistry, 1977; Member of the National Academy of Sciences, 1980; Centenary Lecturer of the Royal Society of Chemistry, 1981-82; Medal of the University of Helsinki, 1983; Award of the Alexander von Humboldt Foundation; Arthur C. Cope Scholar Award, 1989; Honorary doctorate from the University of Lyon, 1994; the Yamada Prize, Japan 2001; the Nobel Laureate Signature Award for Graduate Education of the American Chemical Society, 2002; Ryoji Noyori the Prize, 2013; as well as the August-Wilhelm -von- Hofmann Medal, 2014.

Publications (selection)

Reference Books

  • ML Crawley, BM Trost: Applications of Transition Metal Catalysis in Drug Discovery and Development. John Wiley & Sons, 2012, ISBN 1-118-30983-9 limited preview on Google Book Search
  • B. M. Trost: Stereocontrolled Organic Synthesis. Blackwell Scientific Publications, 1994, ISBN 0-86542-833-6
  • BM Trost, MF bread Hack, I. Fleming: Comprehensive Organic Synthesis: Additions to and Substitutions at CC pi- Bonds. Publisher Elsevier, 1991, ISBN 0-08-040595-9 limited preview on Google Book Search
  • B. M. Trost: Problems in Spectroscopy, W. A. Benjamin Co., 1977
  • BM Trost, LS Melvin: Sulfur Ylides - Emerging Synthetic Intermediates, Academic Press, 1975, ISBN 0-12-701060-2

Articles

  • BM Trost, K. Hirano: Highly Stereoselective Synthesis of α -alkyl- α - Hydroxycarboxylic Acid Derivatives Catalyzed by a Dinuclear Zinc Complex. In: Angewandte Chemie (International edition). Volume 51, Number 26, June 2012, pp. 6480-6483, ISSN 1521-3773. doi: 10.1002/anie.201201116. PMID 22,644,705th
  • BM Trost, G. Dong: Total synthesis of bryostatin 16 using atom- economical and chemo selective Approaches. In: Nature. Volume 456, Number 7221, November 2008, pp. 485-488, ISSN 1476-4687. doi: 10.1038/nature07543. PMID 19,037,312th PMC 2728752 (Free full text ).
  • BM Trost: Asymmetric catalysis: an enabling science. In: Proceedings of the National Academy of Sciences of the United States of America. Volume 101, Number 15, April 2004, pp. 5348-5355, ISSN 0027-8424. doi: 10.1073/pnas.0306715101. PMID 14,990,801th PMC 397 384 (Free full text ). (Review).
  • BM Trost: The atom economy -a search for synthetic efficiency. In: Science. Volume 254, Number 5037, December 1991, pp. 1471-1477, ISSN 0036-8075. PMID 1,962,206th
  • BM Trost: Sculpting horizons in organic chemistry. In: Science. Volume 227, number 4689, February 1985, pp. 908-916, ISSN 0036-8075. PMID 3,969,569th
  • BM Trost: Selectivity: a key to synthetic efficiency. In: Science. Volume 219, Number 4582, January 1983, pp. 245-250, ISSN 0036-8075. doi: 10.1126/science.219.4582.245. PMID 17,798,254th
University of Wisconsin System Trost-Ligand Digital Object Identifier Science (journal) Integrated Authority File
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