Cav1.1

• OMIM: 114208
• UniProt: Q13698
• MGI: 88294

The voltage-dependent L-type calcium channel (also dihydropyridine receptor) is a calcium channel in the cell membrane of the transverse system ( T-tubules ) of muscle cells. However, in cardiac muscle cells they also come to the surface membrane ( calcium induced calcium release ) before. Homologs are found in many chordates. The α1 - subunit ( CACNA1S ) of the protein is controlled by the other subunits, but also works alone. Mutations at CACNA1S gene can lead to periodic paralysis and malignant hyperthermia.

L- type calcium channel is a voltage gated ion channel that the ryanodine receptor in the sarcoplasmic reticulum activated by depolarization of the cell membrane, resulting in an influx of Ca2 ions into the cytosol of muscle cell. This activation occurs in skeletal muscle by protein-protein interaction of the two receptors / channels while a calcium influx from extracellular irrelevant. In contrast, the ryanodine receptor in heart muscle by calcium, which has flowed over the dihydropyridine receptor in the cell, open (calcium - induced calcium release, ICRC ). L- type calcium channel is thus involved in the electro-mechanical coupling.

The inactivation of the channel is slow, which is why it is managed as a longlasting, L -type or CaL channel.

The designation as a " receptor " rather than "channel" lies in the fact that its function was not yet known, as one its affinity for 1,4- dihydropyridines (eg nifedipine, amlodipine, nitrendipine, nimodipine, felodipine or Clevidipine ) discovered which act as antagonists.

• Membrane channel