Cervical intraepithelial neoplasia

The Cervical Intraepithelial Neoplasia (CIN ) represents a force as precancerous dysplasia of the cervix

Disease

The CIN is divided into three levels of severity:

• CIN I ( mild dysplasia ) is made ​​from the basal to a maximum of one third of the height of the epithelium;
• CIN II ( moderate dysplasia) up to two thirds of the epithelium;
• CIN III ( severe dysplasia) throughout almost the entire epithelium ( carcinoma in situ).

Grade I CIN.

Grade II CIN.

Grade III CIN.

The CIN III is considered to be so-called obligate precancerous, which means that a transition to cervical cancer is very likely. Etiology are considered significant protracted HPV infection of the genital type (especially Nos. 16 and 18 ) and high birth rate.

The average age of the patients at the occurrence of CIN I and CIN II is 24-27 years. About half of the CIN 1 lesions regress. Around 10% progressing to CIN III and 2% to invasive cervical carcinoma. The average age of the patients in the discovery of a lesion of the stage CIN III ranks between 35 and 40 years.

Depending on the severity of CIN the further procedure is defined. With a slight dysplasia ( CIN I), one starts from a spontaneous regression rate of 50-70 percent, so it is mainly zuwartend procedure and examined at regular intervals to determine whether and how to further develop dysplasia. In moderate dysplasia ( CIN II ), the regression rate at about 30-50 percent. In this case one decides between a zuwartendem approach with periodic checks or removal of the affected area of the cervix by conization or laser vaporization. In schwergradigen dysplasia ( CIN III), the rate of spontaneous regression is down to 10 percent. Here tend to be more of a cone biopsy should be performed.