CGMP-specific phosphodiesterase type 5

  • CAS Number: 9040-59-9

Phosphodiesterase-5 ( PDE5) is the name of one of the enzymes that cleave the phosphate ester bond in cGMP, with 5'-GMP formed. In humans, the phosphodiesterase -5 is present in the smooth muscle of Penisschwellkörpers ( corpus cavernosum penis ), and the pulmonary arteries. Block cGMP degradation by inhibition of PDE5 ( with for example Sildenafil) leads to more signals of the relaxation pathways and especially to increased blood flow to the erectile tissue, and reducing the pressure in the blood vessels of the lung.

In addition, there are other PDE5, cGMP exclusively cleaving phosphodiesterases. If they are involved in the transmission of visual signals, they appear with the number 6, and if they have manganese as a cofactor, designated by the number 9. PDE11 cleaves both cAMP and cGMP.

Catalyzed reaction

Medical importance

So-called phosphodiesterase -5 inhibitors (PDE -5 ) inhibitors, such as increase sildenafil ( active ingredient of Viagra ® ), tadalafil and vardenafil in the short term, the cGMP concentration, which leads them to a relaxation of the vascular smooth muscle and thus to the far position, which in turn to vermehrtem inflow of blood and an erection of the penis and in the lungs leads to a drop in blood pressure. They are used to treat erectile dysfunction and pulmonary arterial hypertension.

Protein isoform Human Genome Organisation CAS registry number Hydrolysis Euteleostomi Cyclic guanosine monophosphate Smooth muscle tissue Cofactor (biochemistry) PDE5 inhibitor
639722
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