Chloride shift

As Hamburger shift, named after Hartog Jakob Hamburger, in the physiology of anion exchange is referred to in erythrocytes using a Cl-/HCO3--Antiporters. The originating in the periphery diffused from the tissue into the blood capillary and then in the erythrocytes CO2 reacts with H2O, catalyzed by carbonic anhydrase, according to the following equation:

The HCO3- leaves of Hamburg shift the erythrocytes, by the now increased intracellular concentration of H ions occurs in a slight acidification of the erythrocytes and the pH decreases. In cooperation with the increased concentration of CO2, there is a right shift of the oxygen binding curve, and thus in a decrease of the O2 affinity of the hemoglobin ( Bohr effect ), the oxygen is released more easily on the fabric.