Collagenase

Enzymes are called as collagenases which cleave the peptide bond between proline and other amino acids. Thus, these proteases are able to degrade collagen. They occur in higher animals ( Coelomata ), bacteria and some archaea. In humans, five collagenases are known, all of the matrix metalloproteinases ( EC 3.4.24 -. ) Include:

With the help of this enzyme is clostridia can by the breakdown of collagen in the connective tissue spread particularly rapidly. Conversely collagenase is used from Clostridia in support of wound healing ( debridement ).

Biosynthesis

Collagenases of vertebrates arise initially in the form of precursor proteins as procollagenases which must be posttranslationally activated prior to use by enzymatic cleavage.

Dupuytren's contracture

( Manufacturer Pfizer Trade Name Xiapex ) admitted that from the two collagenase enzymes AUX I and AUX II of the bacteria for the treatment of fibrotic strands in the palm and fingers while Dupuytren's disease was established in May 2011 in the European Union, a Microbial collagenase Clostridium histolyticum there that can resolve these when injected into the node.