Congenic

Two organisms or lineages are in genetics as congenic (from Latin con for together, gene genea as a modern neologism to Greek γενεά, descent ', γένεσις génesis, origin '. ) Referred to in that they differ genetically only in a limited section ( a segment ) of chromosomes, differ only by a single gene locus in extreme cases. The ( far more commonly used in technical language ) English equivalent to this is " congenic ". Analogously, those who differ in a complete chromosomes, " konsomisch " (English consomic ) called.

Congenic mice

As model systems for the study of human diseases, designated as strains ( strains engl. ) inbred lines of laboratory mice have been established. Such genetically uniform inbred lines allow einzugerenzen the genetic causes of disease in the model. The problem with this approach is that many, including the medically significant, diseases are caused or influenced by many genes, each of ent in each case only a slight effect on the disease has ( polygeny ). It is very difficult in these cases to establish appropriate inbred strains, since the respective candidate gene isolated in circumstances has no phenological impacts. Therefore, as an alternative, the animal model of congenic strains of mice has been developed. Congenic mice are inbred strains, in which by crossing with subsequent selection controls a short section of the chromosome of another mouse strain has been bred, which typically contains several hundred genes

Swell

• Congenic at Biolohy Online.org