Dengue-Virus

The dengue virus is a virus that can be a hemorrhagic fever, called dengue fever trigger, in humans and other primates. The virus is transmitted by mosquitoes of different species (eg Aedes ). When piercing a primates infected the mosquito picks up the virus, which then propagated further in the mosquito and infects the salivary glands. About the saliva, it is passed in the next stitch.

Features

Dengue virus belongs to the Flaviviridae family, the members will typically have a single stranded RNA genome of positive polarity than that is surrounded by a spherical capsid. The RNA genome is dimerized with the capsid protein C complexed before nucleocapsid. The capsid is surrounded by a membrane derived from the host cell in which the structural proteins M and E are stored. In particular, the protein E is prominent on the surface of the virion and therefore acts as an antigen.

Positivsträngige the RNA about 11,000 nucleotides in length and comprises only one open reading frame encoding a polyprotein. Proteases cut, this polyprotein into three structural (C, prM, E) and the seven non-structural proteins ( NS1, NS2A, NS2B, NS3, NS4A, NS4B, NS5 ); the list corresponds to the arrangement of the coding for the proteins of genes on the genome.