Dexanabinol

• HU -211
• Sinnabidiol
• ( 6aS, 10aS ) -9 - (hydroxymethyl) - 6,6- dimethyl-3 - (2- methyloctane -2-yl ) - 6a, 7,10,10 a- tetrahydrobenzo [c ] chromen -1-ol

Antiemetic

Template: Infobox chemical / molecular formula search available

Dexanabinol (HU -211 ) is a synthetic cannabinoid, which does not bind to CB1 and CB2 receptors.

Chemistry

Dexanabinol is the enantiomer of HU -210, a highly potent cannabinoid. Structurally, it is the mirror image of the side-chain homologue of THC metabolites 11 -hydroxy- Δ9 -tetrahydrocannabinol.

The original synthesis of HU-211 is based on an acid -catalyzed condensation of ( )- myrtenol and 1,1- Dimethylheptylresorcinol (3,5- dihydroxy-1 - (1,1- dimethylheptyl ) benzene ).

It was developed in the laboratory of Raphael Mechoulam at the Hebrew University in Jerusalem. HU -211 does not bind to known cannabinoid receptors, but at NMDA receptor channels and was therefore tested as a potential drug for traumatic brain injury, but was not more effective than placebo in clinical trials.