Diacerein

• 4,5- diacetyloxy -9 ,10- dioxo- anthracene - 2-carboxylic acid
• 1,8 -diacetoxy -3- carboxy anthraquinone
• Diacetylrhein
• Diacerhein

M01AX21

Anti-inflammatory drug

Interleukin -1 inhibitor

Attention

Template: Infobox chemical / molecular formula search available

Diacerein is the international non-proprietary name for the drug 1,8 -diacetoxy -3- carboxy anthraquinone. Diacerein anti-inflammatory properties as an inhibitor of the cytokine interleukin -1 and is used as an active ingredient in some countries for the treatment of osteoarthrosis. A recent study showed a slight, compared with a placebo significant, reduction of pain in the hip joint arthrosis.

Diacerein is diacetylated Rhine (see name), a anthranoid of medicinal rhubarb root. The prodrug of diacerein is deacetylisiert in the liver to the Rhine and excreted 30 % via the kidneys. Unwanted side effects are observed especially in the gastrointestinal tract, the drug can lead to diarrhea.

Trade names

Verboril (A)

In Germany, no drug with this drug is currently approved.