Dihydropyridine

Dihydropyridine

Liquid

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Dihydropyridine is a chemical compound consisting of a six-membered unsaturated ring having one nitrogen atom. It forms the basic structure of the dihydropyridines, which are used in medicine as calcium channel blockers in arterial hypertension. Your unsaturated analogue is the pyridine.

Representation

The reduction of pyridine by means of lithium aluminum hydride gives a mixture of 1,4-dihydropyridine, 1,2- dihydropyridine and 2,5- dihydropyridine. Of pure 1,4-dihydropyridine forms of pyridine in the presence of organic magnesium and zinc complexes.

To prepare highly substituted pyridines using the dihydropyridine by Arthur Hantzsch.

Biological Significance

Dihydropyridine derivatives (eg nifedipine, amlodipine, isradipine, nitrendipine, nimodipine and felodipine ) to the voltage -dependent L -type calcium channel block, that act as antagonists. Before the exact function of this channel enlightenment he was therefore called dihydropyridine receptor.