Emodepside

• IUPAC: Cyclo [ D-2- hydroxypropanoyl -N- methyly -L-leucyl -3-[ 4 - (4 -morpholinyl ) phenyl] - D-2- hydroxypropanoyl -N-methyl -L-leucyl -D-2 - hydroxypropanoyl -N-methyl -L-leucyl -3 - [ 4 - (4 -morpholinyl ) phenyl] - D-2- hydroxypropanoyl -N-methyl -L-leucyl ]

QP52AA51

White to yellowish, odorless powder

Anthelmintics

Practically insoluble in water ( 5.2 mg · l-1 at pH 7)

Template: Infobox chemical / molecular formula search available

Emodepside is employed in veterinary medicine anthelmintic with a broad spectrum of activity against nematodes. It is a semi-synthetic derivative of the fermentation product of the fungus Mycelia sterilia. It is in combination with praziquantel under the brand name Profender (Bayer AG) for application to the skin (spot on) approved in cats as well as in tablet form for oral input for dogs and under the trade name Procox as an oral solution in combination with toltrazuril for dogs.

The drug blocks the neuromuscular junction of the pharynx and the body musculature of nematodes and leads to paralysis of the parasites. The drug accumulates in adipose tissue after application and is released slowly from there. The elimination half -life is about 9 days.

Side effects

Occasionally in cats at the site of application to whitish residue or hair loss. With ten times the recommended daily dose, there is a slight salivation and slight muscle spasms that disappear after stopping the product.

In dogs, the active ingredient should be entered on an empty stomach, to provide a slow release. In dogs with the MDR1 (- / - ) of the drug has a narrow therapeutic window: Even at double the recommended dose can in these animals nausea and unsteadiness may occur. For all other dogs, these symptoms can very rarely when administered with the feed and thus to occur faster drug release. The side effects disappear without treatment within a day, a specific antidote is not known.