Ethyl biscoumacetate

• Bis (4- hydroxy-2 -oxo -2H- chromen- 3-yl) - acetic acid ethyl ester
• Ethyl-2 ,2-bis (4-hydroxy -2-oxo -2H- chromen- 3-yl ) acetate

B01AA08

Bimorph crystals

Anticoagulants

Vitamin K antagonist

177-182 ° C and 154-157 ° C

3.1

• 750 mg · kg -1 ( LD50, mouse, oral)
• 840 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Ethylbiscoumacetat is the international non-proprietary name of bis (4-hydroxy -2-oxo -2H- chromen- 3-yl) - acetic acid ethyl ester, a chemical compound from the group of 4- hydroxycoumarins with anticoagulant effect.

• 3.1 Mechanism of action ( pharmacodynamics )
• 3.2 Absorption and distribution in the body ( pharmacokinetics )

Chemistry

Ethylbiscoumacetat crystallizes in two different forms ( Bimorphismus ) which differ by their melting point.

Clinical information

Areas of application (indications )

It is used for the controlled anticoagulation, for example in the treatment or prevention in a tendency to thrombotic diseases.

Adverse effects (side effects)

As a possible side effect Ethylbiscoumacetat can facilitate bleeding and hematoma due to its inhibition of coagulation, but there may also be fever, nausea and diarrhea or rash of the skin.

Pharmacological properties

Mechanism of action ( pharmacodynamics )

It exerts its protein anticoagulation by inhibiting the enzymatic reduction of vitamin K. It acts just like any other Coumarinvarianten, such as acenocoumarol, dicoumarol or warfarin.

Uptake and distribution in the body ( pharmacokinetics )

Ethylbiscoumacetat is taken orally and is finally largely absorbed by the body. In the circulation and bind it to 95% of the modified proteins of the blood plasma, and finally it is reduced again by the liver.