Etilefrine

  • (± )-N- Ethylnorphenylephrin
  • (RS ) -1 - ( 3-hydroxyphenyl ) - 2 - ( ethylamino ) ethanol
  • DL -1-( 3-hydroxyphenyl ) - 2 - ( ethylamino ) ethanol
  • (±) -1 - ( 3-hydroxyphenyl ) - 2 - ( ethylamino ) ethanol
  • C10H15NO2 ( Etilefrin )
  • C10H15NO2 · HCl ( Etilefrin · hydrochloride)
  • 709-55-7 ( Etilefrin )
  • 534-87-2 ( Etilefrin · hydrochloride)

C01CA01

Sympathomimetic

Fixed

Hydrochloride

Attention

114 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Etilefrin is a drug which is used for circulatory disorders associated with low blood pressure (hypotension ), dizziness, unexplained fatigue, weakness, fibrillation and blackening go before his eyes. Etilefrine is used as a mixture of enantiomers (racemate ) in the form of the hydrochloride

Mechanism of Action

The substance is a direct sympathomimetic with α - and β - sympathomimetic effect. The α -adrenergic effect on α - adrenergic receptors on the blood vessels leads to vasoconstriction and thus to several hours lasting increase in blood pressure. Same time, since a β -adrenergic effect is that caused by the influence on the β - adrenergic receptors of the heart, there is also an increase in the impact frequency (pulse ) and impact strength ( inotropy ) of the heart. The half-life ( elimination ) is about 2 hours.

Adverse effects (selection )

  • Palpitation
  • Ventricular arrhythmia
  • Angina pectoris - like symptoms
  • Voiding dysfunction through stimulation of the bladder sphincter ( interference with emptying of the bladder )
  • Restlessness
  • Increased sweating
  • Insomnia

Contraindications (selection)

  • Hyperthyroidism ( overactive thyroid pathological )
  • Pheochromocytoma ( tumor of noradrenaline, adrenaline and metanephrines produced )
  • Benign prostatic hyperplasia with residual urine ( benign enlargement of the prostate)
  • Cardiac arrhythmia
  • Valvular stenosis (narrowing of the heart valves)
  • Cardiomyopathy ( heart muscle disease)

Doping

Etilefrin is in the list of the World Anti -Doping Agency ( WADA) listed as a stimulant that is banned during athletic competitions.

Trade names

Bioflutin (D), Effortil (D, A, CH), Pholdyston (D), Thomasin (D), Etil (D), Etilefrin (D)

Etilefrin in combination with dihydroergotamine in liquid form as Agilan (A), Effortil plus (D, CH), Dihydergot plus (D)

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Dangerous Substances Directive (67/548/EEC) Active ingredient Epinephrine
297482
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