Fructose-bisphosphate aldolase

Aldolase ( detail fructose -1 ,6 -bisphosphate aldolase ) is the enzyme that catalyzes the cleavage of fructose- 1 ,6 -bisphosphate into dihydroxyacetone phosphate ( DHAP ) and glyceraldehyde -3- phosphate ( GADP ). This reaction is a partial step of glycolysis and thus indispensable for the utilization of carbohydrates in all living things. Three isoforms of the enzyme are known in vertebrates, which are located in the muscles (A), the liver and erythrocytes (B) and in the brain (C) and are encoded by their own genes. Mutations in one of these genes can lead to Aldolasemangel. Missing, for example, the aldolase A, this can lead to rhabdomyolysis and a form of hemolytic anemia.

Aldolase B is called because of their occurrence and liver aldolase, but it is also present in the kidney. It is the evolutionarily oldest isoform and the one that is found in bacteria and plants.

Assembly of H -ATPase

Aldolase B has another function, which is important particularly in the kidneys. There constantly will be held reabsorption of blood components by endocytosis. Requirement for the regulation of vesicles and other cell interior by means of acidification is the V-type ATPase, transport proteins in the respective membrane, which are assembled from a plurality of subunits. For this assembly aldolase B is essential; this function is completely independent of said enzymatic function.