Fusaric acid

• Fusaric acid
• 5 - butyl-pyridine - 2-carboxylic acid
• 5-n- butylpicolinic

Colorless light-sensitive crystals

Fixed

108-109 ° C

Attention

180 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Fusaric acid is a picolinic acid derivative, which is formed as a secondary metabolite of plant-damaging fungi of the genus Fusarium and the type Gibberella fujikuroi.

Fusaric acid has herbicidal, insecticidal and antibacterial effects. It is for a plant wilt toxin ( causes premature wilting ), on the animal organism it works but only weakly toxic. It inhibits dopamine β -hydroxylase (an enzyme which converts dopamine to norepinephrine ), has a blood pressure lowering activity, and has an influence on the properties of the membrane of cells. It works partially synergistically with other mycotoxins such as deoxynivalenol (DON). Therefore, their importance is not fully understood as a mycotoxin.

History

Fusaric acid was first published in 1934 by Teijiro Yabuta at the University of Tokyo as a metabolite of the rice -damaging fungus Gibberella fujikuroi ( Fusarium moniliforme ) identified.