GGPS1

GGPP synthetase ( GGPPSase ) is the enzyme in animals that (IPP ) molecules catalyzes the condensation reaction of several isopentenyl diphosphate with dimethylallyl diphosphate (DMAPP ) to farnesyl diphosphate, two steps in the biosynthesis of cholesterol. A further step towards geranylgeranyl diphosphate ( GGPP ) is possible; GGPP participates in post-translational modification of proteins plays a role in cell apoptosis. In humans GGPPSase is found in all tissues, but is expressed at particularly high levels in the testes.

Catalyzed reactions

⇔ PPi

Isopentenyl diphosphate (IPP ) and dimethylallyl diphosphate (DMAPP ) condense to form geranyl diphosphate.

⇔ ⇔ PPi

Isopentenyl diphosphate (IPP ) and condense to form farnesyl geranyl diphosphate.

Human Genome Organisation Transferase Isopentenyl pyrophosphate
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