Gliadorphin

Gliadorphin referred to in some publications as gluteomorphin, is an exogenous opioid peptide, called Exorphin, which may arise in the digestion of gluten contained in gliadin.

Structure

Gliadorphin is composed of seven amino acids heptapeptide. The amino acid sequence Tyr-Pro -Gln -Pro -Gln- Pro-Phe ( in single letter code: YPQPQPF ). The sum formula is C43H57N9O11 and the molar mass is 875.4 g · mol -1.

Effect

Normally Gliadorphin is completely decomposed by enzymes in digestion. This also applies to other exogenous opioid peptides, such as in milk casomorphin. There is some evidence that a gluten-free diet the symptoms in autistic children significantly alleviates. Perhaps these children lack the enzymes to degrade gluten in the body. Furthermore, it is assumed that the incomplete degraded exorphins then connect in the brain of affected children to the corresponding opioid receptors where they exert their opioid effect. This hypothesis is the basis for the Gfcf diet (gluten - free casein - free diet gluten-and casein-free diet = ). The topic is very controversial among experts.