Granuloma inguinale

Granuloma inguinale is a bacterial disease, which has a characteristic ulcerative lesions in the genital area. Also known under the name Donovanosis after the discoverer of pathognomonic histological structures. The pathogen is Klebsiella granulomatis (formerly Callymmatobacterium granulomatis ), or granuloma genitoinguinale.

It is endemic in many developing countries. Due to several problems ( which apply to almost all STD) remains granuloma inguinale there often untreated and can destructively grow.

In addition to painless ulcers, which can be confused with syphilis, this stride eventually continued in the destruction of tissue and pronounced hemorrhage. This surface decomposition leads to an increased risk of further microbial superinfections and can also lead to mutilation.

Diagnosis

Diagnosis is based on history and clinical examination, showing a painless ulcer with a characteristic rolled edge of granulation tissue. Contrary to ulceration, which can be found in syphilis, there is usually no lymph node involvement. Tissue biopsies and a Wright - Giemsa stain help diagnose survey. Here show up in the deep purple coloring the Donovan bodies as rod-shaped oval organisms in the cytoplasm of macrophages or histiocytes.

Therapy

The treatment can be carried out with co-trimoxazole, tetracyclines or macrolides.

References and sources

• WHO. Retrieved on July 3, 2011.

• Venereology