Granulosa cell tumour

Granulosa cell tumors of the ovary are with niedrigmaligner potency. They are counted among the mesenchymal and hormone-producing ovarian tumors.

Epidemiology

The peak age of the disease is 45-55 years. They account for 1-2% of all ovarian tumors. There are two histological types, the juvenile and the adult granulosa cell tumors. The juvenile granulosa cell tumors can develop in infants and children already.

Symptoms

Due to the mass it is generally non-specific symptoms such as pressure and bloating, constipation or increase in abdominal girth. For larger tumors may lead to a stem rotation with subsequent acute abdomen.

In 25% of cases there is estrogen formation, resulting in women to glandular- cystic or adenomatous hyperplasia of the endometrium with possible bleeding between periods, precocious in girls in a pseudo - puberty. After menopause bleeding is thus also possible. Through the duration of estrogen stimulation of the endometrium endometrial cancer can be triggered in 5-10%.

Diagnosis

Gynecological examination, vaginal ultrasound, fractional curettage ( scraping ) to the exclusion of a corpus carcinoma.

Therapy

Surgical removal of the tumor together with the affected ovary.

In advanced tumors, chemotherapy can be performed. Children and young people are treated as part of the Makei therapy study of the Society for Pediatric Oncology and Hematology ( GPOH ).

Forecast

The 10 - year survival rate is about 90%. In case of a metastasis in the abdominal cavity or lymph nodes, the prognosis is worse.