HBG1

  • OMIM: 142200

Subunit Hemoglobin gamma -1 is a protein, for encoding the known human HBG1 gene.

Function

The gamma globin genes ( HBG1 and HBG2 ) usually manifest themselves in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains fetal Hömoglobin ( HbF ), which is replaced at birth usually through the Hömoglobin adult ( HbA ). In some beta- thalassemias and related conditions, the production of gamma chains continues even in adulthood. The two types of gamma chains differ at residue 136, where you will find at the G- gamma production ( HBG2 ) glycine and in the A- gamma production ( HBG1 ) alanine. The former is predominant at birth. The order of the genes in the beta -globin cluster is: 5 ' - ε - γ -G - γ -A - δ - β - 3'.

Protein subunit Dominance (genetics) Gene cluster HBE1 HBD Blood (journal) Digital Object Identifier PubMed Central Nucleic Acids Research Biochimica et Biophysica Acta
379557
de