Hyperostosis

As hyperostosis ( bone overgrowth or bone hyperplasia Syn ) is called a pathological proliferation of the bone, which can be directed both inward ( endosteal hyperostosis ) and externally ( exostosis, cortical hyperostosis ). In a narrower sense hyperostosis are bone diseases with increase in bone density, ie the ratio of bone mass and volume.

Causes

Hyperostosis, can have many causes. Common to them is that there is a dysfunction of osteoclasts and / or osteoblasts, which leads to increased bone formation. Main triggers are

• Irritation: mostly localized hyperostosis
• Endocrine disorders: hyperparathyroidism, hypothyroidism, acromegaly
• Metabolic disorders: chronic renal failure,
• Poisoning ( fluorides, lead, vitamin A, arsenic, bismuth, strontium, beryllium, phosphorus)
• Hereditary diseases: juvenile Paget's Disease ( Hyperostosis cortical juvenilis deformans ), van Buchem syndrome ( cortical hyperostosis generalisata ), osteopetrosis, sickle cell anemia
• Idiopathien, diseases of unknown cause: Caffey syndrome ( cortical hyperostosis infantilis ), hyperostosis frontalis interna in the Morgagni 's syndrome, Cavarial - hyperostosis syndrome
• Rheumatoid and age-related diseases: SAPHO syndrome, Forestier 's disease ( vertebral hyperostosis senilis ankylans )
• Chronic infections: tuberculosis
• Paraneoplastic syndromes: Pachydermoperiostosis with lung cancer, leukemia