Inhibitory postsynaptic potential

The inhibitory (inhibitory ) postsynaptic potential ( IPSP ) (English inhibitory postsynaptic potential, inhibere from the Latin " inhibit ") is a local change in the membrane potential at the postsynaptic membrane of animal and human nerve cells, which leads to the excitation of the cell by hyperpolarization of the inhibited cell membrane at the synapse and initiation of action potentials by excitatory postsynaptic potentials ( EPSP) is difficult.

The transmitter of inhibitory synapses elicit a cellular response channels are opened by the postsynaptic in the membrane that allow the specific potassium or chloride ions pass. The opening of these ion channels, it usually comes at a potassium ion efflux from the nerve cell or to a chloride ion influx into the nerve cell. In both cases, there is thus a ( first local ) hyperpolarization of the postsynaptic membrane or to conditions that impede or prevent the formation of action potentials.

Swell

• R. Klinke, St. Silbernagl (ed.): Textbook of Physiology. 4th edition. Thieme- Verlag, 2003, ISBN 3-13-796004-5.

• Neurophysiological potential