Klaus-Peter Lesch

Klaus -Peter Lesch ( born March 4, 1957 in Würzburg ) is a German psychiatrist and professor at the University of Würzburg.

Training

Lesch studied from 1977 to 1983 medicine at the universities of Würzburg ( Germany ), Bern ( Switzerland ) and Cape Town ( South Africa). During his studies he became a member of Corps Bavaria Würzburg. In 1984 he earned his doctorate at the Department of Neurology at the University Hospital of Würzburg, where he worked from 1985 to 1990 as an assistant physician at the Clinic for Psychiatry and Psychotherapy.

Scientific career

From 1990 to 1992 he was a Fogarty Research Fellow in the Department of Neuropharmacology, under the direction of Dennis L. Murphy at the National Institute of Mental Health in Bethesda, Maryland / USA, worked.

At the University of Würzburg, he was from 1993 to 1995 senior physician and group leader in the Department of Psychiatry and Psychotherapy. After his habilitation he had a Hermann and Lilly Schilling Foundation Professorship in Würzburg from 1995 to 2000 for clinical neuroscience.

Full Professorship

Since 2001, Klaus -Peter Lesch Associate Professor of Psychiatry and Psychotherapy at the Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg and runs since 2004 a Clinical Research Unit for the Study of Aufmerksamkeitsdefizit-/Hyperaktivitäts-Syndroms. Since 2010 he has simultaneously worked at the Institute for Translational Neuroscience at the School for Mental Health and Neuro Sciences ( MHENS ) of the University of Maastricht in the Netherlands as a professor.

In Würzburg, Lesch has the Department of Molecular Psychiatry since 2010 and is director of the Laboratory for Translational Neuroscience.

At the University of Tartu in Estonia Lesch is currently a visiting professor at the Faculty of Social Sciences and Education since 2011.

Research

Among the most important research areas of Klaus -Peter Lesch include:

  • Molecular neurobiology of cognitive control
  • Epigenetics in brain development and neuronal plasticity
  • Functional Imaging
  • Animal models of attention, cognition and learning / memory
  • Pathogenetic mechanisms of Aufmerksamkeitsdefizit-/Hyperaktivitäts-Syndroms (ADHD), anxiety disorders, depression and substance abuse

Other professional activities

Since 2007, Lesch founding member of the European Neuroscience and Society Network ( ENSN ). He is also a member of several national and international advisory bodies.

Awards

Important publications

  • Lesch KP, Bengel D, salvation A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996 ) Association of anxiety -related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1532
  • Canli T, Lesch KP ( 2007) Long story short: the serotonin transporter in emotion regulation and social cognition. Nature Neurosci 10:1103-1109
  • Murphy DL, Lesch KP ( 2008) Targeting the murine serotonin transporter: insights into human neurobiology. Nat Rev Neurosci 9:85-96
  • Lesch KP, Selch S, Renner TJ, Jacob C, Nguyen TT, Hahn T, Romanos M, Shoichet S, Dempfle A, Heine M, Boreatti - Hümmer A, Walitza S, Romanos J, Gross- Lesch S, Zerlaut H, Allolio B, Heinzel S, Fassnacht M, portcullis A, Wultsch T, Schäfer H, Warnke A, Reif A, Ropers HH, Ullmann R ( 2011) Genome -wide copy number variation analysis in ADHD: association with neuropeptide Y gene dosage extended in to pedigree. Mol Psychiatry 16:491-503
  • Lesch KP, Waider J (2012 ) Serotonin in the modulation of neural plasticity and networks: implications for neurodevelopmental disorders. neuron 76:175-191
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