Laudanosine

• (1S ) -1 - [(3,4 -dimethoxyphenyl ) methyl] -6,7- dimethoxy -2-methyl -3 ,4- dihydro-1H- isoquinolin
• N- Methyltetrahydropapaverin

89 ° C

Insoluble in ethanol, chloroform and diethyl ether

Risk

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Laudanosine is a poisonous alkaloid Benzylisochinoline, which is found in small quantities in opium poppy and structurally related to papaverine (N -methyl- tetrahydropapaverine ).

Furthermore, it is a potentially toxic degradation product of the muscle relaxants atracurium and (to a lesser extent ) cisatracurium.

Laudanosine crosses the blood -brain barrier and acts via interactions with GABA, opioid and nicotinic acetylcholine receptors epileptogenic, ie cerebral arousing. It can increase the cardiovascular system to decrease in blood pressure (hypotension) lead and slowed heart rate (bradycardia ). In practice, the effects of laudanosine in the usual doses of muscle relaxants in general, however, play no role. It also increases the MAC value of the volatile anesthetics used in anesthesia. Laudanosine is excreted renally.