Levodropropizine

(S) -3 - (4- phenylpiperazine -1-yl ) propane -1 ,2 -diol

R05DB27

Antitussive

102-104 ° C

Template: Infobox chemical / molecular formula search available

Levodropropizine is a drug from the group of antitussives ( cough charming painkillers ). It is used for irritation and spasmodic cough and irritation of the upper respiratory tract. In case of hepatic or renal impairment, severe cardiovascular disorders and children under 2 years of active substance can not be used. For use in pregnancy or lactation has not been established. At high doses it can cause a short-term drop in blood pressure and heart palpitations. Occasionally, fatigue, nausea, vomiting, mild diarrhea, dizziness and headaches may occur, rarely, allergic reactions.

Levodropropizine contains at Propandiolrest a stereogenic center as it is (S)- enantiomer ( eutomer ) is used.

Production

The preparation of levodropropizine dropropizine from the racemate with the aid of lipase from Pseudomonas cepacia, described in the literature.