Levosalbutamol

  • (R)- Albuterol
  • (R) -2 - (tert- butylamino ) -1 - (4- hydroxy-3- hydroxymethylphenyl ) ethanol
  • C13H21NO3 ( Levosalbutamol )
  • C13H21NO3 · HCl ( Levosalbutamol · hydrochloride)
  • C13H21NO3 · 1/2 H2SO4 ( Levosalbutamol · sulphate)
  • 34391-04-3 ( Levoalbutamol )
  • 50293-90-8 ( Levosalbutamol · hydrochloride)
  • 148563-16-0 ( Levosalbutamol · sulphate)

R03AC

β2 -sympathomimetic

β2 -adrenoceptor agonist

  • 239.31 g · mol -1 ( Levosalbutamol )
  • 275.78 g.mol -1 ( levosalbutamol · hydrochloride)
  • 576.71 g · mol -1 ( Levosalbutamol · sulphate)

Template: Infobox chemical / molecular formula search available

Levosalbutamol is a drug from the group of β2 -agonists, which is used as a bronchodilator in bronchial asthma and chronic obstructive bronchitis. Levosalbutamol causes, administered by inhalation, a rapid onset and long-lasting relaxation (relaxation) of the smooth muscles in the bronchi. The effect is based on the stimulation of β2 -adrenoceptors.

Stereoisomerism

Levosalbutamol is the international non-proprietary name ( INN) of the enantiomerically pure ( R)-isomer of salbutamol, which is chiral, ie contains a stereocenter. Levosalbutamol represents the active enantiomer ( = eutomer ) of salbutamol dar.

The racemic salbutamol other hand consists of two enantiomers, (R) -2 - (tert- butylamino ) -1 - (4- hydroxy-3- hydroxymethylphenyl ) ethanol, and (S) -2 - (tert- butylamino ) -1 - ( 4- hydroxy-3- hydroxymethylphenyl ) ethanol, in a 1:1 ratio.

Production

Several multistep syntheses for Levosalbutamol are described in the literature.

Finished medicinal product

Vento Plus ( AR), Xopenex (USA)

The inhalation solutions containing the respective well water-soluble Levosalbutamolhydrochlorid or Levosalbutamolhemitartrat.

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Active ingredient Argentina
509749
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