Mallory body

In so-called Mallory bodies are inclusion bodies in cells of the liver, which were first described by the American pathologist Frank Burr Mallory (1862-1941) described In order to appreciate the later contribution of the Graz pathologists Helmut thinking about their further research, is the name Mallory- thinking body been proposed.

Mallory bodies occur particularly in alcohol -toxic hepatitis, but also occur in other diseases of the liver such as, for example, primary biliary cirrhosis or Wilson's disease. The mechanisms involved in the formation are complex and include, among other things, a protein misfolding, changes of chaperone proteins and a disproportionate expression of cytokeratins.