Melorheostosis

The Melorheostosis (Greek: μέλι = honey, ῥεῦμα = flow, ὀστέον = bone) is a rare thickening of the bone, usually on the extremities. The bone metabolism is disturbed.

Synonyms

After the first person to describe the Melorheostosis also Léri syndrome ( André L., neurologist, Paris, 1875 - 1930) called. Because of the radiographic appearance of the names candle wax disease, wax bone disease are common. English: Léri 's melorheostosis, Léri - Joanny syndrome, candle bone disease.

Causes

Genetic factors: function -reducing mutations in LEMD3/MAN1-Gen be accepted as the cause of the disease.

Symptoms

Often the disease makes no discomfort and is discovered as an incidental finding on radiographs. Sometimes the thickened hinder the tendon or joint function. In rare cases, they bridge the growth plates and thus lead to stunted growth.

Diagnostics

The diagnosis is made on the radiograph. The compacted districts remember wax drops that flow out of a candle.

Therapy

Treatment is necessary only in the rare cases when motion disabilities or growth disturbances. Then the extra bone to be surgically removed.