MEN1

Menin is a protein that participates in DNA repair and development processes in the nucleus of vertebrates and insects. The exact function is still unclear. Since a lack of Menin can lead to tumors, it also uses the outdated term tumor suppressor. In humans, Menin is produced in many tissue types. Meninmangel by mutations in the MEN1 gene ( chromosome region 11q13 ) leads to multiple endocrine neoplasia type 1

When DNA damage occurs in large amounts in Menin phosphorylated form. It can bind to different DNA forms. Protein binding partners include FANCD2 and DBF4 and complexes with MLL. Menin participant in the MAPKKK signaling cascade. Menin can delay the G2/M-Phasenübergang about the up-regulation of CDK inhibitors and reduce the cyclin B2 expression. It participates in development processes and on gestational diabetes.

Protein isoform Human Genome Organisation Digital Object Identifier
563822
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