Ménétrier's disease

As Ménétrier syndrome (syn.: Crohn Ménétrier, hypertrophic gastropathy, Menetrier, Ménétrier giant hypertrophic gastritis, according to Pierre E. Ménétrier, 1859-1935 ) refers to a disorder of the stomach, which is a significant increase in the mucosal folds (10-20 mm ) and broadening of the slime-forming epithelium comes. Among the main and parietal cell atrophy. This leads to a hypo- up inacidity: It is made at little or no stomach acid. The increased mucus production leads to a loss of protein. The Ménétrier syndrome is one of the exudative gastroenteropathies. Histology shows foveoläre hyperplasia.

The cause is unknown. Maybe an infection with Helicobacter pylori is a factor. Symptoms include abdominal pain, nausea and vomiting, diarrhea (caused by the high protein content of the gut ), anemia and edema ( by the enteral protein loss). Malignant degeneration is possible in about 10 % of cases. The diagnosis is primarily by an esophago-gastro - duodenoscopy ( EGD ) with biopsies. Play a lesser role the gastrointestinal passage ( MDP), endoscopic ultrasonography, a Gordon - test and laboratory findings ( proteins, electrophoresis, Hb). The syndrome -like symptoms were found in mice with histamine H2- receptor was off.

Treatment is symptomatic, and any HP eradication. Due to the degeneracy of risk are performed regular check- gastroscopy.