Methoxyflurane

  • Methoxyflurane
  • IUPAC: 2,2-dichloro- 1, 1 - difluoro- 1- methoxyethane
  • Latin: Methoxyfluranum

N01AB03

Flammable, volatile, colorless liquid

Inhalation anesthetic

Liquid

1.44 g · cm -3 ( 25 ° C)

-35 ° C

104.5 ° C ( 101.325 kPa)

32 hPa (at 20 ° C)

Sparingly soluble in water ( 28.6 g · l-1 at 37 ° C)

Attention

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Methoxyflurane is a chemical substance in the group of Flurane. It was used as an inhalation anesthetic since 1960 until the early seventies.

Properties

Methoxyflurane is an inflammatory, volatile, colorless liquid which is sparingly soluble in water.

The degradation of methoxyflurane in the body falls at a particularly high concentration of inorganic fluoride, the toxic effects are attributed. Therefore, it is no longer clinically used. With a minimal alveolar concentration of 0.16, it is very potent. The very high fat solubility a very slow drain and rise in level, which is due in anesthesia disadvantage.

Physical data:

  • Metabolic rate: 50 %
  • Blood - gas partition coefficient: 12

Safety

The vapors of methoxyflurane can combine with air to form an explosive mixture (flash point 37 ° C).

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Vapor pressure Dangerous Substances Directive (67/548/EEC) Halogenated ether Inhalational anaesthetic
566189
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