Methylisothiazolinone

• 2-methyl- 2H-isothiazol -3-one
• 2-methyl- 4-isothiazolin -3-one
• Methylisothiazolone
• MI
• WITH
• NEOLONE ™ 950

Colorless solid

Fixed

1.39 g · cm -3 ( 20 ° C)

39 to 42.8 ° C

Very slightly soluble in water (> 4200 g · l-1 at 22 ° C)

Risk

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Methylisothiazolinone (MIT ) belongs to the class of compounds isothiazolinones and is a widely used biocide.

Properties

Chemical Properties

Methylisothiazolinone can be eliminated in the environment by hydrolysis, photolysis, and by microbial degradation by nucleophiles. The hydrolysis is carried out in neutral and acidic medium slow. In the basic range, a rapid degradation was observed.

Use

Methylisothiazolinone has a microbicidal effect and is used as a preservative in cosmetics, household and industrial cleaners, in water treatment, in lubricants, emulsion paints, varnishes, adhesives and in the manufacture of paper. Often mixtures with chloromethylisothiazolinone ( CMIT ) or benzisothiazolinone be used. According to a study contained 2000 in Switzerland, 43% of paints, varnishes and coatings, the mixture CMIT / MIT. For adhesives, fillers and gaskets were 45%.

Biological Significance

In cosmetics, the blend of Methylisothiazolinone and chloromethylisothiazolinone lead to allergies. Around 2% of the population will react to these ingredients allergic. Even when staying in freshly painted rooms allergies can occur.

In recent years, however, the sole use of methylisothiazolinone (without chloromethylisothiazolinone ) has led to more frequent adverse skin reactions. The Association of European cosmetics industry ( Cosmetics Europe ) recommends that ( leave-on products) and to dispense with remaining on the skin products for cosmetic wet wipes on the use of Methylisothiazolinone. Sensitization to methylisothiazolinone by products that are washed off ( rinse-off products ), are not to be expected.