MHC restriction

MHC restriction describes that antigens of T lymphocytes can only be detected when processed previously and specific endogenous receptor to the major histocompatibility complex ( MHC) encoded Class I and Class II protein complex presented on the cell surface be.

The MHC restriction is a term from immunology, was introduced in 1974 in two pioneering work of Rolf Zinkernagel and Peter Doherty. For their achievements in medical research, both received in 1996 the Nobel Prize for Medicine.