Molybdenum cofactor

Moco

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Molybdenum cofactor ( Moco, molybdenum cofactor of English ) is a cofactor in various enzymes causes molybdenum -catalyzed metabolic reactions.

Properties

It is a coordination compound between molybdopterin and a molybdenum oxide. The Molydopterin needed is synthesized from guanosine triphosphate. A genetic defect in the biosynthesis of the molybdenum cofactor leads to epileptic seizures in newborns, progressive encephalopathy, dysmorphic features of the face and difficulty in feeding.

The molybdenum cofactor is used in enzymes such as Sulfitoxidasen, the xanthine oxidases and aldehyde oxidase.

The enzymes in plants and animals use the side of the tricyclic molybdenum cofactor. All previously discovered molybdenum -containing enzymes use this cofactor bind up on the phylogenetic alternative molybdenum -containing nitrogenase, the nitrogen in some bacteria and cyanobacteria. Molybdenum-containing enzymes found in plants and animals and sometimes catalyze the oxidation of the reduction of certain molecules as a part of the nitrogen, sulfur and carbon circuits.

In mammals, the molybdenum cofactor date occurs in four enzymes are referred to the ( sulferase English Moco C -terminal domain) as MOSC.

In plants, four Moco - containing enzymes are known so far, nitrate reductase, sulfite oxidase, xanthine dehydrogenase and aldehyde oxidase.

In Escherichia coli over 50 different enzymes with molybdenum cofactors are known.