Nitazoxanide

Nitazoxanide is a drug from the class of antiparasitic agents. It is a synthetic 5 - Nitrothiazolyl - salicylamide derivative for the treatment of parasitic infestation. Nitazoxanide in Germany has no authorization.

Effect

The effect is probably due to an interference with the pyruvate - ferredoxin oxidoreductase ( PFOR ) -dependent transfer of electrons that control energy metabolism in the parasite.

Pharmacology

With oral administration of fatty food potentiates the efficacy. Shares are metabolized to the active gastrointestinal tizoxanide - Metabolyten with almost complete protein binding. The maximum tizoxanide plasma levels reached after 1-4 hours. It is excreted via bile and deconjugation in the feces, as well as glucuronate and unchanged tizoxanide on kidney and urine.

Areas of application

Treatment of infestations with:

  • Giardia intestinalis
  • Cryptosporidium.

Therapeutic efficacy in Infestation with:

  • Entamoeba histolytica
  • Isospora belli
  • Cyclospora cayetanensis
  • Helminthiosen Beef tapeworm
  • Dwarf tapeworm
  • Roundworm
  • Pinworm
  • Whipworm
  • Hookworms
  • Stercoralis

Nitazoxanide shows antibacterial activity in:

Anti- viral activity in:

Contraindications

A risk - benefit assessment of potential reproductive toxicity is required.

Side effects

Possible side effects include:

  • Nausea
  • Vomit
  • Stomach ache
  • Diarrhea
  • Hives
  • Itching

Therapy control

During treatment with nitazoxanide a Infestations control by detection of cysts is indicated in the chair.

Active ingredient Giardia lamblia Taenia saginata Trichuris trichiura
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