Nucleotide salvage

Salvage pathway ( German Bergungsweg ) is generally the term used for metabolic pathways accomplish the synthesis of a biomolecule from its breakdown products - a form of recycling. In particular, is the one meant by the salvage pathway for purine nucleotides.

Purine nucleotide salvage

The salvage pathway is used in the cytoplasm of the formation of mononucleotides from the free purine bases adenine, guanine and hypoxanthine. In addition to the degradation to uric acid it represents 90% of the primary route for free purines dar. It is significantly more energy efficient than the de novo biosynthesis of Purinmononukleotiden.

Method

On a free purine base, a ribose phosphate from phosphoribosyl pyrophosphate ( PRPP ) is transmitted with the elimination of pyrophosphate. In this case, the corresponding nucleotide is formed.

The catalyzing enzymes are allosterically activated by PRPP and inhibited by their products.

Clinic

If a defect occurs in the salvage pathway, it may come to hyperuricemia.

A genetic defect of HGPRT leads to Lesch -Nyhan syndrome.