Octenidine dihydrochloride

  • N-octyl -1-[ 10 - (4- octyliminopyridin -1-yl ) decyl ] pyridin-4 -imine (IUPAC)
  • N, N'-( decane -1 ,10- diyldi -1 ( 4H) -pyridyl -4- ylidene) bis ( octylammonium ) dichloride
  • Octenidinum (Latin )
  • 71251-02-0
  • 70775-75-6 ( dihydrochloride)
  • D08AJ57
  • G01AX66

Antiseptic

215-217 ° C. ( dihydrochloride)

  • 800 mg · kg -1 ( LD50, Rat, oral, dihydrochloride)
  • 10 mg · kg -1 ( LD50, rat, iv, dihydrochloride)

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Octenidine is a broad spectrum antiseptic for disinfecting the skin and mucous membranes and to disinfect wounds.

Area of ​​application

Octenidine is for the disinfection of skin and mucosal wounds, usually used together with 2% phenoxyethanol. It is also used before surgery in the anal and genital area as well as in preparation for the laying of a bladder catheter.

Spectrum

Octenidine is bactericidal against both Gram- positive and -negative bacteria, virucidal against lipophilic viruses such as the herpes simplex virus and the hepatitis B virus. In addition, it is fungicidal, but not against spores.

Advantages / Disadvantages

Benefits

  • Odorless
  • Colorless
  • Painless application
  • Broad spectrum of activity
  • Remanence

Disadvantages

  • Cartilage toxicity ( may just as polyhexanide not be applied to cartilage tissue and in the inner ear or in the vicinity of the eardrum )
  • Not approved for flushing the abdominal cavity and urinary bladder
  • Compared with povidone - iodine comparatively expensive
  • Some manufacturers no longer permitted probes for the care of (eg PEG )
  • Not for long-term use ( > 2 weeks )
  • Not to be used under occlusion

Notes

With simultaneous use of PVP - iodine -based antiseptics may brownish come in the border area to to purple skin discoloration.

When the supply of stab wounds about the hand area - as well as generally in the treatment of wound cavities with Octenidine - it must be ensured that the preparation can flow, as it can lead to massive edema and tissue damage otherwise that may need to be repaired surgically.

Trade names

Octenidine, Octenisept ( with phenoxyethanol ), Octeniderm (with 1 -propanol and 2 -propanol), Octenisept wound gel, mouthwash octenidol

CAS registry number PubChem Anatomical Therapeutic Chemical Classification System Disinfectant Virucide Fungicide 1-Propanol Isopropyl alcohol
613564
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