Pamoic acid

  • IUPAC: 4,4 ' -methylenebis ( 3-hydroxy- 2-naphthoic acid )
  • Pamoic

Yellow needles

Fixed

≥ 300 ° C ( decomposition)

  • PKS1 = 2.51
  • PKa2 = 3.1
  • Insoluble in water, ethanol and diethyl ether
  • Soluble in nitrobenzene and pyridine

Attention

390 mg · kg -1 ( LD50, mouse, ip)

Template: Infobox chemical / molecular formula search available

Embonic acid or pamoic acid is a derivative of naphthalene-2 ​​-carboxylic acid (2- naphthoic acid ). It arises from the reaction of 3 -hydroxy-2 -naphthoic acid with formaldehyde. The salts of the embonic are called embonates or pamoates.

Use

Embonic forms with basic drugs usually very sparingly soluble salts from which the active ingredient is released slowly. Such embonates are therefore used in pharmaceuticals as a depot dosage forms.

Origin of the name

Embonic acid, the term is an abbreviation for the chemical name 4,4 ' -methylenebis ( 3-hydroxy- 2-naphthoic acid ). The origin of the name pamoic is not sure. He probably derives from the antimalarial agent Pamaquin. This was the first liquid base which was used as a solid pamoate.

CAS registry number PubChem Dangerous Substances Directive (67/548/EEC) Intraperitoneal injection Base (chemistry)
306096
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