Pelger–Huet anomaly

The Pelger -Huet anomaly core is a genetic malformation of the nuclear leukocytes.

This autosomal dominant disease is characterized in that it comes to Hyposegmentation of granulocytes. Thus, the nuclei have a maximum of two core segments. However, the function of leukocytes is not or very little affected by it. In the homozygous form the cores are all unsegmented and round. In the heterozygous form of the cores have mostly two segments.

The Pelger -Huet anomaly core must be distinguished from the so-called pseudo - Pelger. This is due to an underlying disease for short-term occurrence of these Hyposegmentation. Triggering conditions can be including various forms of leukemia, severe infections or vitamin B12 or folic acid deficiency.

Swell

• Paul Frick: blood and bone marrow morphology. Thieme, Cologne 2003. P.29

• Hereditary disease
• Disease in hematology and oncology