Pipamperone

IUPAC: 1 - [4 - ( 4-fluorophenyl )-4- oxobutyl ] - 1,4- bipiperidine -4- carboxamide

N05AD05

Antipsychotic

From 124.5 to 126 ° C ( pipamperone dihydrochloride )

Dihydrochloride

Attention

160 mg · kg -1 ( LD50, rat, oral)

Template: Infobox chemical / molecular formula search available

Pipamperone is a psychotropic drug from the group of low-potency neuroleptics. Accordingly, it is significantly less sedating and antipsychotic effect.

Desirable effects

The gift of pipamperone to and the like help regulate total in restlessness, insomnia, mood swings. In addition, existing agitation or aggression may be reduced.

Adverse effects

In comparison to other antipsychotics to pipamperone distinguished by its relative compatibility, anticholinergic side effects are not given. Therefore, it is also often used in the Geronto and child and adolescent psychiatry.

In higher doses it can cause extrapyramidal motor disturbances, called dyskinesias, divided into Frühdyskinesie and tardive dyskinesia. This is about movement disorders, mainly in the orofacial ( around the mouth or face ) area. They can occur as early or tardive dyskinesia, which is a low pipamperone potent neuroleptic and tardive dyskinesia occur, especially with high-potency typical neuroleptics.

Very rarely does that happen neuroleptic malignant syndrome, which can be life threatening.

Gastrointestinal symptoms: loss of appetite, nausea to vomiting.

Endocrine effects: hyperprolactinaemia, breast enlargement, menstrual disorders.

Cardiovascular Effects: Accelerated pulse, low blood pressure, very rarely cardiac arrhythmias ( QT prolongation) before, in one case there was a cardiac arrest.

Other complaints in the CNS: occasionally been reported depression, fatigue and dizziness, insomnia, headaches and seizures.

Physical withdrawal symptoms: insomnia.

Application

Pipamperone is usually prescribed as sleeping tablets. It is also used in the treatment of elderly people and in mental illness as a sedative. Furthermore, it is administered to children with aggressive behavior. The plasma half-life amounts to 17-22 hours.

Trade names

Dipiperon (D, CH ), various generics (D)