Piroctone olamine

5000 mg · kg -1 ( LD50, mouse, oral)

Template: Infobox chemical / molecular formula search available

Piroctone olamine (INN ) is the ethanolamine salt of a derivative of 2- pyridone. It is a fungicide and antibacterial substance from the class of pyridones.

Use

Fungicidal effect

Piroctone olamine is due to its fungicidal (medical mostly: antimyzetischen ) effect an additive in many anti -dandruff shampoos. It has to all medically relevant dermatophytes, yeasts and molds fungicidal activity. The active ingredient may penetrate the cell wall of yeasts such as Malassezia furfur, and complexes of iron ( III) ions. This results in inhibition of the energy metabolism in the mitochondria of fungi result.

Piroctone olamine is much more effective than other antifungals the pyridone series, such as ciclopirox or pyrithione. One for the cosmetics industry also important advantage is that the active ingredient in surfactants, a further additive of shampoos triggers. In this case, the finished product must have a pH between 6 and 7, with higher values ​​shows Piroctone olamine no effect.

Piroctone olamine was first mass produced by Hoechst AG. Under the brand name Octopirox ® was first used in the manufactured of Schwarzkopf & Henkel Dusseldorf ( subsidiary of Hoechst) in July 1979 Haarwasser Seborin ®. Meanwhile, the connection in many cosmetic products for the treatment of dandruff ( Pityriasis simplex capillitii ) is contained in shampoos for dogs and cats.

Bactericidal effect

Piroctone olamine shows next to the fungicide and bactericidal activity against gram-positive and gram-negative bacteria.